Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids

Author:

Pritchett Beau P.12345ORCID,Stoltz Brian M.12345ORCID

Affiliation:

1. The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering

2. Division of Chemistry and Chemical Engineering

3. California Institute of Technology

4. Pasadena

5. USA

Abstract

The development of new heterocyclic substrate classes for palladium-catalyzed allylic alkylation has enhanced synthetic access to structurally diverse monoterpene indole alkaloids.

Funder

National Institute of General Medical Sciences

Gordon and Betty Moore Foundation

California Institute of Technology

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference87 articles.

1. J. E. Saxton , The Alkaloids: Chemistry and Biology , ed. G. A. Cordell , Academic Press , San Diego, CA , 1998 , vol. 51 , pp. 1–197

2. T.-S. Kam and K.-H.Lim , The Alkaloids: Chemistry and Biology , ed. G. A. Cordell , Elsevier , Amsterdam , 2008 , vol. 66 , pp. 1–111

3. Collective synthesis of natural products by means of organocascade catalysis

4. A Concise and Versatile Double-Cyclization Strategy for the Highly Stereoselective Synthesis and Arylative Dimerization of Aspidosperma Alkaloids

5. Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine via Late-Stage Oxidation of (+)-Fendleridine Derivatives

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