A lithium-doped surface inspires immunomodulatory functions for enhanced osteointegration through PI3K/AKT signaling axis regulation

Author:

Peng Feng12ORCID,Qiu Longhai1,Yao Mengyu1,Liu Lidan3,Zheng Yufeng14ORCID,Wu Shuilin5,Ruan Qingdong2,Liu Xuanyong3ORCID,Zhang Yu1,Li Mei1ORCID,Chu Paul K.2ORCID

Affiliation:

1. Department of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China

2. Department of Physics, Department of Materials Science and Engineering, and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China

3. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

4. School of Materials Science and Engineering, Peking University, Beijing 100871, China

5. School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China

Abstract

The response of immune systems is crucial to the success of biomedical implants in vivo and in particular, orthopedic implants must possess appropriate immunomodulatory functions to allow sufficient osteointegration.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

City University of Hong Kong

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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