One-pot synthesis of tri- and di-fluoromethylated bis(indolyl)methanols <i>via</i> Friedel–Crafts-type acylation and alkylation-Reference-Cited by-同舟云学术

One-pot synthesis of tri- and di-fluoromethylated bis(indolyl)methanols via Friedel–Crafts-type acylation and alkylation

Published:2022 Issue:37 Volume:20 Page:7491-7498
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wu Xian-Tao¹,Ma Feng¹,Xiao En-Kai¹,Yin Jin¹,Sun Fuxing²^ORCID,Wang Qiang³,Jiang Yi-Jun¹^ORCID,Chen Peng¹^ORCID

Affiliation:

1. School of Materials Science and Chemical Engineering, Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, P. R. China

2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China

3. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, P. R. China

Abstract

The first synthesis of tri- and di-fluoromethylated bis(indolyl)methanols through a one-pot Friedel–Crafts-type acylation–alkylation under metal-, additive-, toxic-solvent-, and protective-gas-free conditions.

Funder

Natural Science Foundation of Ningbo

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01281B

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1. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

2. Fluorinated poly(arylene ether ketone)s for high temperature dielectrics