Influence of sequence variation on the RNA cleavage activity of Zn<sup>2+</sup>-dimethyl-dppz-PNA-based artificial enzymes-Reference-Cited by-同舟云学术

Influence of sequence variation on the RNA cleavage activity of Zn²⁺-dimethyl-dppz-PNA-based artificial enzymes

Published:2022 Issue:9 Volume:12 Page:5398-5406
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Luige Olivia¹^ORCID,Karalė Kristina¹²^ORCID,Bose Partha Pratim¹^ORCID,Bollmark Martin²,Tedebark Ulf²,Murtola Merita¹,Strömberg Roger¹^ORCID

Affiliation:

1. Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 83 Huddinge, Sweden

2. RISE, Department of Chemical Process and Pharmaceutical Development, Forskargatan 18, 15136 Södertälje, Sweden

Abstract

The ability of Zn2+ dimethyl-dppz PNAzymes to cleave RNA target sequences with under 20 minute half-lives is critically dependent on the bulge-closing base pairs as well as their stacking interactions with the neighbouring nucleobases.

Funder

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA08319H

Reference27 articles.

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