Computational analysis revealing that K634 and T681 mutations modulate the 3D-structure of PDGFR-β and lead to sunitinib resistance-Reference-Cited by-同舟云学术

Computational analysis revealing that K634 and T681 mutations modulate the 3D-structure of PDGFR-β and lead to sunitinib resistance

Published:2017 Issue:60 Volume:7 Page:37612-37626
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Nemaysh Vishal¹²³⁴⁵,Luthra Pratibha Mehta¹²³⁴⁵^ORCID

Affiliation:

1. Neuropharmaceutical Chemistry Research Laboratory

2. Dr B. R. Ambedkar Center for Biomedical Research

3. University of Delhi

4. Delhi-110007

5. India

Abstract

Platelet-derived growth factor receptor-beta (PDGFR-β) is expressed by endothelial cells (ECs) of tumor-associated blood vessels and regulates primarily early hematopoiesis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA01305A

Reference55 articles.

1. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

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