Computational analysis revealing that K634 and T681 mutations modulate the 3D-structure of PDGFR-β and lead to sunitinib resistance
Author:
Affiliation:
1. Neuropharmaceutical Chemistry Research Laboratory
2. Dr B. R. Ambedkar Center for Biomedical Research
3. University of Delhi
4. Delhi-110007
5. India
Abstract
Platelet-derived growth factor receptor-beta (PDGFR-β) is expressed by endothelial cells (ECs) of tumor-associated blood vessels and regulates primarily early hematopoiesis.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA01305A
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