High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination-Reference-Cited by-同舟云学术

High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination

Published:2022 Issue:19 Volume:10 Page:5707-5718
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhai Yuanxin¹²^ORCID,Wang Quanwei²,Zhu Zhanchi¹²,Hao Ying¹²³^ORCID,Han Fang¹²,Hong Jing¹²,Zheng Wenlong⁴,Ma Sancheng⁴,Yang Lingyan¹²³,Cheng Guosheng¹²³^ORCID

Affiliation:

1. School of Nano-Tech and Nano Bionics, University of Science and Technology of China, Hefei Anhui 230026, China

2. CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou Jiangsu 215123, China

3. Guangdong Institute of Semiconductor Micro-Nano Manufacturing Technology, Guangdong 528200, China

4. Suzhou Kowloon Hospital, Shanghai Jiaotong University Medical School, Suzhou Jiangsu 215123, China

Abstract

The schematic illustration of the effect of the brain-targeted engineered exosome-mediated BDNF on oligodendrocyte differentiation in vitro and remyelination in vivo through intranasal administration.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00518B

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1. Pathology of multiple sclerosis and related inflammatory demyelinating diseases