Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition-Reference-Cited by-同舟云学术

Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition

Published:2023 Issue:76 Volume:59 Page:11397-11400
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Timmers Matt¹²^ORCID,Peeters Wouter³,Hauwert Niels J.⁴^ORCID,Rijcken Cristianne J. F.²,Vermonden Tina¹^ORCID,Dijkgraaf Ingrid³^ORCID,Liskamp Rob M. J.²³⁵^ORCID

Affiliation:

1. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, The Netherlands

2. Cristal Therapeutics, Maastricht 6229 EV, The Netherlands

3. Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, The Netherlands

4. Symeres, Kerkenbos 1013, Nijmegen 6546 BB, The Netherlands

5. School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK

Abstract

The N-terminal specific attachment of the reactive TMTHSI-click handle to peptides and proteins is described followed by strain-promoted cycloaddition with azide containing peptides, proteins, nucleic acids, or other small or large azide compounds.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC03397J

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2. TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

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