Calibration methods to circumvent unknown component spectra for quantitative in situ Raman monitoring of co-polymerization reactions

Author:

Rusli Wendy1234ORCID,Naraharisetti Pavan Kumar12345ORCID,Chew Wee6278ORCID

Affiliation:

1. Institute of Chemical and Engineering Sciences

2. A*STAR (Agency for Science, Technology and Research)

3. Jurong Island

4. 627833 Singapore

5. Newcastle University in Singapore

6. Singapore Institute of Food and Biotechnology Innovation

7. Nanos

8. 138669 Singapore

Abstract

PLS, MMSR, and BTEM-MLR were successfully applied to Raman monitoring of co-polymerization.

Funder

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Reference36 articles.

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2. N. L. Jestel , in Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries , ed. K. A. Bakeev , John Wiley & Sons, Ltd , 2nd edn, 2010 , pp. 195–243

3. B. Sonnleitner , in Measurement, Monitoring, Modelling and Control of Bioprocesses , ed. C.-F. Mandenius and N. J. Titchener-Hooker , Springer Berlin Heidelberg , Berlin, Heidelberg , 2013 , pp. 1–33

4. Trends in process analytical technology

5. Using PAT to accelerate the transition to continuous API manufacturing

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