Visible-light mediated oxidative ring expansion of anellated cyclopropanes to fused endoperoxides with antimalarial activity

Author:

Budde Simon123,Goerdeler Felix4563ORCID,Floß Johannes123,Kreitmeier Peter123,Hicks Elliot F.78910,Moscovitz Oren4563,Seeberger Peter H.456311ORCID,Davies Huw M. L.78910ORCID,Reiser Oliver123ORCID

Affiliation:

1. Universität Regensburg

2. 93053 Regensburg

3. Germany

4. Max Planck Institute of Colloids and Interfaces

5. Department of Biomolecular Systems

6. 14476 Potsdam

7. Department of Chemistry

8. Emory University

9. Atlanta

10. USA

11. Institute of Chemistry and Biochemistry

Abstract

Hetero- and carbocyclic anellated cyclopropanes were converted in one step by a visible light induced photooxidation to their corresponding polycyclic endoperoxides, which show promising antimalarial activity.

Funder

Deutsche Forschungsgemeinschaft

Center for Selective C-H Functionalization, National Science Foundation

Max-Planck-Gesellschaft

Friedrich-Ebert-Stiftung

Alexander von Humboldt-Stiftung

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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