Absorption rate governs cell transduction in dry macroporous scaffolds-Reference-Cited by-同舟云学术

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Absorption rate governs cell transduction in dry macroporous scaffolds

Published:2023 Issue:7 Volume:11 Page:2372-2382
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

VanBlunk Madelyn¹²^ORCID,Srikanth Vishal³^ORCID,Pandit Sharda S.¹²^ORCID,Kuznetsov Andrey V.³²^ORCID,Brudno Yevgeny¹²⁴^ORCID

Affiliation:

1. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, USA

2. Comparative Medicine Institute, North Carolina State University, USA

3. Department of Mechanical and Aerospace Engineering, North Carolina State University, USA

4. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA

Abstract

Dry, macroporous scaffolds efficiently transduce T cells, but the mechanism for this transduction has not been studied previously. We report that liquid volume and resultant differences in liquid absorption rates governs cell transduction efficiency.

Funder

National Cancer Institute

National Science Foundation

Alexander von Humboldt-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01753A

Reference45 articles.

1. Natural and synthetic biomaterials for controlled drug delivery

2. Natural and Synthetic Polymers as Drug Carriers for Delivery of Therapeutic Proteins

3. Alginate-Based Biomaterials for Regenerative Medicine Applications

4. Biomaterials for recruiting and activating endogenous stem cells in situ tissue regeneration

5. Polymeric materials for immune engineering: Molecular interaction to biomaterial design

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1. Implantable CAR T cell factories enhance solid tumor treatment;Biomaterials;2024-07

2. A biomaterial platform for T cell-specific gene delivery;Acta Biomaterialia;2024-03

3. Biomaterials to enhance adoptive cell therapy;Nature Reviews Bioengineering;2024-01-26

4. Mechanical forces amplify TCR mechanotransduction in T cell activation and function;Applied Physics Reviews;2024-01-19

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