A targeted delivery strategy for the development of potent trypanocides-Reference-Cited by-同舟云学术

A targeted delivery strategy for the development of potent trypanocides

Published:2017 Issue:62 Volume:53 Page:8735-8738
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gordhan Heeren M.¹²³⁴,Milanes Jillian E.⁵⁶²³⁴,Qiu Yijian⁵⁶²³⁴,Golden Jennifer E.⁷⁸⁹¹⁰⁴^ORCID,Christensen Kenneth A.¹¹¹²¹³⁴,Morris James C.⁵⁶²³⁴^ORCID,Whitehead Daniel C.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Clemson University

3. Clemson

4. USA

5. Eukaryotic Pathogens Innovation Center

6. Department of Genetics and Biochemistry

7. Department of Pharmaceutical Sciences

8. School of Pharmacy

9. University of Wisconsin

10. Madison

11. Department of Chemistry and Biochemistry

12. Brigham Young University

13. Provo

Abstract

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds againstTrypanosoma brucei, the causative agent of African sleeping sickness.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC03378H

Reference18 articles.

1. History of Sleeping Sickness in East Africa

2. The trypanosomiases

3. A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

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