Fenton-like reaction of the iron(ii)–histidine complex generates hydroxyl radicals: implications for oxidative stress and Alzheimer's disease-Reference-Cited by-同舟云学术

Fenton-like reaction of the iron(ii)–histidine complex generates hydroxyl radicals: implications for oxidative stress and Alzheimer's disease

Published:2021 Issue:92 Volume:57 Page:12293-12296
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wang Can¹,Wang Zheng¹^ORCID,Zeng Binglin¹,Zheng Meiqing²,Xiao Nao¹^ORCID,Zhao Zhongwei¹³^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China

2. Core Facility Center, Capital Medical University, Beijing 100069, China

3. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

Abstract

Fenton-like reaction of the iron(ii)–histidine complex, one major iron(ii) species in blood plasma, occurs at neutral pH, generating hydroxyl radicals and the iron(iii)–histidine complex found in Alzheimer's disease.

Funder

Natural Science Foundation of Beijing Municipality

Beijing Municipal Commission of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC05000A

Reference41 articles.

1. Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis

2. Mechanisms of cardiac iron homeostasis and their importance to heart function

3. Iron and oxidizing species in oxidative stress and Alzheimer's disease

4. Detection and identification of the oxidizing species generated from the physiologically important Fenton-like reaction of iron(II)-citrate with hydrogen peroxide

5. Targeting Free Radicals in Oxidative Stress-Related Human Diseases

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