Synthesis of 2-trifluoromethyl thiazoles <i>via</i> [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF<sub>3</sub>CN-Reference-Cited by-同舟云学术

Synthesis of 2-trifluoromethyl thiazoles via [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF₃CN

Published:2022 Issue:44 Volume:20 Page:8761-8765
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yao Yunfei¹²,Lin Bo²,Wu Minze¹,Zhang Yafang¹,Huang Yangjie¹,Han Xiaoyan³,Weng Zhiqiang¹²^ORCID

Affiliation:

1. Fujian Engineering Research Center of New Chinese lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China

2. Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

3. Testing and Analysis Center, Soochow University, Suzhou 215123, China

Abstract

A [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF3CN for the synthesis of 2-trifluoromethyl 4,5-disubstituted thiazoles is reported.

Funder

Minjiang University

Fuzhou University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01749K

Reference35 articles.

1. Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery