Advantages of using biologically generated <sup>13</sup>C-labelled multiple internal standards for stable isotope-assisted LC-MS-based lipidomics-Reference-Cited by-同舟云学术

Advantages of using biologically generated ¹³C-labelled multiple internal standards for stable isotope-assisted LC-MS-based lipidomics

Published:2023 Issue:24 Volume:15 Page:2925-2934
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Jaber Malak A.¹²^ORCID,de Falco Bruna²^ORCID,Abdelrazig Salah²^ORCID,Ortori Catharine A.²,Barrett David A.²^ORCID,Kim Dong-Hyun²^ORCID

Affiliation:

1. Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan

2. Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

Abstract

An in vivo multiple labelling strategy using P. pastoris to generate 300 + 13C-labelled internal standards was shown to significantly reduce technical variations introduced in typical human lipidomics analyses using >100 samples and >70 h run time.

Funder

University of Petra

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AY/D3AY00460K

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