Cation-controlled chemoselective synthesis of N-aroylureas and imides via amidation of N-Boc arylamides-Reference-Cited by-同舟云学术

Cation-controlled chemoselective synthesis of N-aroylureas and imides via amidation of N-Boc arylamides

Published:2023 Issue:8 Volume:10 Page:2061-2069
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Jiamin¹²³,Shuai Sujuan¹²³,Gan Lishe³⁴,Luo Yongxin⁴,Jin Huimin¹²³,Chen Lingfeng¹,Zou Dong¹²³^ORCID,Liang Guang¹,Walsh Patrick J.⁵^ORCID,Li Jie¹²³^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 311399, China

2. Department of Pharmacy, School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, P. R. China

3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China

4. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, People's Republic of China

5. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA

Abstract

In this study, the first highly chemoselective amidation of Boc and amide groups of N-R-N-Boc arylamides is advanced.

Funder

Natural Science Foundation of Zhejiang Province

National Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00352C

Reference64 articles.

1. Synthesis and Insecticidal Activities of Novel Anthranilic Diamides Containing Acylthiourea and Acylurea

2. Acylthiourea, Acylurea, and Acylguanidine Derivatives with Potent Hedgehog Inhibiting Activity

3. Virtual Screening-Based Discovery and Mechanistic Characterization of the Acylthiourea MRT-10 Family as Smoothened Antagonists

4. Talin Modulation by a Synthetic N-Acylurea Derivative Reduces Angiogenesis in Human Endothelial Cells

5. Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents