TMAO and urea in the hydration shell of the protein SNase-Reference-Cited by-同舟云学术

TMAO and urea in the hydration shell of the protein SNase

Published:2017 Issue:9 Volume:19 Page:6345-6357
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Smolin Nikolai¹²³⁴,Voloshin Vladimir P.⁵⁶⁷,Anikeenko Alexey V.⁵⁶⁷⁸⁶,Geiger Alfons⁹¹⁰¹¹¹²¹³,Winter Roland⁹¹⁰¹¹¹²¹³^ORCID,Medvedev Nikolai N.⁵⁶⁷⁸⁶^ORCID

Affiliation:

1. Department of Cell and Molecular Physiology

2. Loyola University Chicago

3. Maywood

4. USA

5. Institute of Chemical Kinetics and Combustion

6. 630090 Novosibirsk

7. Russia

8. Novosibirsk State University

9. Physikalische Chemie

10. Fakultät für Chemie und Chemische Biologie

11. Technische Universität Dortmund

12. 44221 Dortmund

13. Germany

Abstract

We performed all-atom MD simulations of the protein SNase in aqueous solution and in the presence of two major osmolytes, trimethylamine-N-oxide (TMAO) and urea, as cosolvents at various concentrations and compositions and at different pressures and temperatures.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CP/C6CP07903B

Reference94 articles.

1. Living with Water Stress: Evolution of Osmolyte Systems

2. The Control of Protein Stability and Association by Weak Interactions with Water: How Do Solvents Affect These Processes?

3. A Naturally Occurring Protective System in Urea-Rich Cells: Mechanism of Osmolyte Protection of Proteins against Urea Denaturation