Nanospheres based on PLGA/amphiphilic cyclodextrin assemblies as potential enhancers of Methylene Blue neuroprotective effect

Author:

Cannavà C.12345,Stancanelli R.67829,Marabeti M. R.10115,Venuti V.1213145,Cascio C.10115,Guarneri P.10115,Bongiorno C.15165,Sortino G.1718192021,Majolino D.1213145,Mazzaglia A.1718192021,Tommasini S.67829,Ventura C. A.67829

Affiliation:

1. Dipartimento di Patologia Umana dell’adulto e dell’età evolutiva “Gaetano Barresi”

2. Università di Messina

3. Policlinico Universitario

4. I-98125-Messina

5. Italy

6. Dipartimento di Scienze Chimiche

7. Farmaceutiche

8. Biologiche ed Ambientali

9. I-98168 Messina

10. CNR-IBIM Istituto di Biomedicina e Immunologia Molecolare

11. I-90146 Palermo

12. Dipartimento di Scienze Matematiche e Informatiche

13. Scienze Fisiche e Scienze della Terra

14. I-98166 Messina

15. CNR-IMM Istituto di Microelettronica e Microsistemi

16. I-95121 Catania

17. CNR-ISMN

18. Istituto per lo Studio dei Materiali Nanostrutturati

19. c/o Dipartimento di Scienze Chimiche

20. Biologiche

21. Farmaceutiche ed Ambientali dell' Università

Abstract

Nanospheres of amphiphilic cyclodextrin and PLGA entrapping Methylene Blue are proposed as potential enhancers of drug neuroprotective effect on neuroblastoma cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference55 articles.

1. “Lest we forget you — methylene blue …”

2. L. M. Moreira , J. P.Lyon, A. P.Romani, D.Severino, M. R.Rodrigues and H. P. M.de Oliveira, Phenotiazinium dyes as photosensitizers (PS) in photodynamic therapy (PDT): Spectroscopic properties and photochemical mechanisms, in Advanced Aspects of Spectroscopy, ed. M. A Farrukh, InTech Open, 2012, pp. 393–422

3. Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications

4. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways

5. Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats

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