Synthesis of novel thiadiazole derivatives as selective COX-2 inhibitors-Reference-Cited by-同舟云学术

Synthesis of novel thiadiazole derivatives as selective COX-2 inhibitors

Published:2016 Issue:12 Volume:7 Page:2309-2327
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ragab Fatma A.¹²³⁴,Heiba Helmi I.⁵⁶⁷⁸⁴,El-Gazzar Marwa G.⁵⁶⁷⁸⁴,Abou-Seri Sahar M.¹²³⁴,El-Sabbagh Walaa A.⁵⁶⁷⁸⁴,El-Hazek Reham M.⁵⁶⁷⁸⁴

Affiliation:

1. Department of Pharmaceutical and Medicinal Chemistry

2. Faculty of Pharmacy

3. Cairo University

4. Egypt

5. Department of Drug Radiation Research

6. National Centre for Radiation Research and Technology (NCRRT)

7. Egyptian Atomic Energy Authority (EAEA)

8. Cairo

Abstract

A novel series of thiadiazole derivatives were designed and synthesized for evaluation as selective COX-2 inhibitors in vitro and were investigated in vivo as anti-inflammatory and analgesic agents against carrageenan-induced rat paw oedema model in irradiated rats.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00367B

Reference37 articles.

1. Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study

2. CYCLOOXYGENASES 1 AND 2

3. Anti-inflammatory drugs and their mechanism of action

4. Synthesis of Novel Substituted Thiourea and Benzimidazole Derivatives Containing a Pyrazolone Ring as Anti-Inflammatory Agents

5. Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, structure, and formation paths of functionally substituted thiadiazolopyrimidines;Russian Chemical Bulletin;2024-04

2. Selective synthesis of thiadiazolo-2H-chromen-2-ones and chromeno-thiadiazolo-pyrimidines under thermal conditions and microwave irradiation catalyzed by calixarene-based ionic liquid immobilized on magnetic nanoparticles;Journal of Molecular Liquids;2024-03

3. Synthesis, Characterization, and Biological Evaluation of Novel Thiadiazole-incorporated Aminothiazole Derivatives as Potential Anticancer Agents;Russian Journal of Organic Chemistry;2023-08

4. Pyrazole-sulfonamide scaffold featuring dual-tail strategy as apoptosis inducers in colon cancer;Scientific Reports;2023-04-08

5. Challenging breast cancer through novel sulfonamide–pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis;Future Medicinal Chemistry;2023-01