Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab

Author:

Samsudin Firdaus123ORCID,Yeo Joshua Yi123,Gan Samuel Ken-En12345ORCID,Bond Peter J.12367

Affiliation:

1. Bioinformatics Institute (A*STAR)

2. Singapore 138671

3. Singapore

4. p53 Laboratory (A*STAR)

5. Singapore 138648

6. Department of Biological Sciences

7. National University of Singapore

Abstract

The IgM antibody isotype of Pertuzumab affords simultaneous binding to antigens, but similar binding in Trastuzumab is hindered by steric clashes.

Funder

Bioinformatics Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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