Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab
Author:
Affiliation:
1. Bioinformatics Institute (A*STAR)
2. Singapore 138671
3. Singapore
4. p53 Laboratory (A*STAR)
5. Singapore 138648
6. Department of Biological Sciences
7. National University of Singapore
Abstract
The IgM antibody isotype of Pertuzumab affords simultaneous binding to antigens, but similar binding in Trastuzumab is hindered by steric clashes.
Funder
Bioinformatics Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC04722K
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