Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide-Reference-Cited by-同舟云学术

Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide

Published:2020 Issue:3 Volume:11 Page:826-832
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Fang-Yi¹²³⁴⁵,Zhang Zhen-Feng⁶⁷⁸⁹⁵,Voss Stephanie¹⁰¹¹¹²¹³¹¹,Wu Yao-Wen¹⁰¹¹¹²¹³¹¹^ORCID,Zhao Yu-Fen¹²³⁴⁵,Li Yan-Mei¹²³⁴⁵^ORCID,Chen Yong-Xiang¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education)

2. Department of Chemistry

3. Tsinghua University

4. Beijing 100084

5. China

6. State Key Laboratory of Microbial Resources

7. Institute of Microbiology

8. Chinese Academy of Sciences

9. Beijing 100101

10. Chemical Genomics Centre of the Max Planck Society

11. 44227 Dortmund

12. Germany

13. Max-Planck-Institute of Molecular Physiology

Abstract

A membrane l_d microdomain-targeting hybrid peptide displays potent inhibition effect toward K-Ras4B-plasma membrane interaction and impairs Ras signaling output.

Funder

Knut och Alice Wallenbergs Stiftelse

Deutsche Forschungsgemeinschaft

National Natural Science Foundation of China

National Basic Research Program of China

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC04726C