Microwave-assisted synthesis of arene ruthenium(ii) complexes [(η6-RC6H5)Ru(m-MOPIP)Cl]Cl (R = -H and -CH3) as groove binder to c-myc G4 DNA-Reference-Cited by-同舟云学术

Microwave-assisted synthesis of arene ruthenium(ii) complexes [(η6-RC6H5)Ru(m-MOPIP)Cl]Cl (R = -H and -CH3) as groove binder to c-myc G4 DNA

Published:2014 Issue:24 Volume:43 Page:9216-9225
ISSN:1477-9226
Container-title:Dalton Trans.
language:en
Short-container-title:Dalton Trans.

Author:

Wu Qiong¹²³,Chen Tianfeng⁴⁵³,Zhang Zhao¹²³,Liao Siyan⁶⁷³,Wu Xiaohui¹²³,Wu Jian¹²³,Mei Wenjie¹²³⁴⁵,Chen Yanhua¹²³,Wu Weili¹²³,Zeng Lingli¹²³,Zheng Wenjie⁴⁵³

Affiliation:

1. School of Pharmacy

2. Guangdong Pharmaceutical University

3. Guangzhou, P.R. China

4. Department of Chemistry

5. Jinan University

6. School of Pharmaceutical Sciences

7. Guangzhou Medical University

Abstract

Two arene Ru(ii) complexes are prepared under microwave irradiation and display application potential as small molecule inhibitors of c-myc G4 DNA.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/DT/C3DT53635A

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1. The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

2. A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest

3. Secalonic Acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3β/β-catenin/c-Myc pathway

4. BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

5. G-quadruplex DNA: A target for drug design

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