Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from <i>Cephalotaxus fortunei</i>-Reference-Cited by-同舟云学术

Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from Cephalotaxus fortunei

Published:2022 Issue:35 Volume:20 Page:7076-7084
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhao Chun-Xue¹,Liu Hui²,Zhang Xin¹,Yang Meng-Yue¹,Wang Yue-Tong²,Xing Yi-Jia¹,Hua Jun-Xin¹,Zhang Qin¹,Li Da-Hong¹^ORCID,Bai Jiao¹,Jing Yong-Kui²,Hua Hui-Ming¹^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, China

2. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 10016, PR China

Abstract

1 is the first nitrogen-oxidized homoerythrina-type alkaloid isolated from Cephalotaxus genus. 31 exhibited a significant antitumor effect in THP-1 and K562 cancer cell lines with GI50 values of 0.24 and 0.29 μM.

Funder

National Science and Technology Major Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01242A

Reference33 articles.

1. W. J.Zheng and L. G.Fu , Flora of China , Science Press , Beijing , 1978 , vol. 7 , pp. 423–432

2. Cephalodiones A–D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition

3. Diterpenoids from Cephalotaxus fortunei var. alpina and their cytotoxic activity

4. 17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei

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