Mesoporous ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses

Author:

Afroz Sumbul12345ORCID,Medhi Himadri6375,Maity Somedutta6375,Minhas Gillipsie12345,Battu Srikanth12345,Giddaluru Jeevan12345ORCID,Kumar Koushi6375,Paik Pradip6375ORCID,Khan Nooruddin12345ORCID

Affiliation:

1. School of Life Sciences

2. Department of Biotechnology and Bioinformatics

3. University of Hyderabad

4. Hyderabad-500046

5. India

6. School of Engineering Sciences and Technology

7. Hyderabad 500046

Abstract

Herein, we have designed novel mesoporous ZnO (mZnO) nanocapsules with a size of ∼12 nm and loaded them with Ova protein. In vivo studies in mice highlight the potency of the antigen loaded mZnO nanocapsules as an efficient adjuvant and vaccine delivery vehicle.

Funder

Nano Mission Council, Department of Science and Technology

Department of Science and Technology, Ministry of Science and Technology

University Grants Commission

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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