An advanced biphasic porous and injectable scaffold displays a fine balance between mechanical strength and remodeling capabilities essential for cartilage regeneration

Author:

Zavala Gabriela123,Viafara-García Sergio M.123,Novoa Javier123,Hidalgo Carmen123,Contardo Ingrid14,Díaz-Calderón Paulo14,Alejandro González-Arriagada Wilfredo15,Khoury Maroun123,Acevedo Juan Pablo123ORCID

Affiliation:

1. Centro de Investigación e Innovación Biomédica (CIIB), Universidad de los Andes, Chile

2. Cells for Cells and REGENERO, The Chilean Consortium for Regenerative Medicine, Santiago, Chile

3. IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile

4. Facultad de Medicina, Escuela de Nutrición y Dietética, Biopolymer Research & Engineering Laboratory (BiopREL), Universidad de los Andes, Chile

5. Facultad de Odontología, Universidad de los Andes, Chile

Abstract

An important challenge in tissue engineering is the regeneration of functional articular cartilage (AC).

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Reference45 articles.

1. The Biomechanics of Cartilage—An Overview

2. S. J.Gilbert and E. J.Blain , Cartilage mechanobiology: How chondrocytes respond to mechanical load, editor:Mechanobiology in Health and Disease , Elsevier , 2018 , pp. 99–126

3. The Basic Science of Articular Cartilage: Structure, Composition, and Function

4. Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis

5. Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine

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