Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo-Reference-Cited by-同舟云学术

Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo

Published:2018 Issue:10 Volume:9 Page:1722-1732
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Lu Shan¹²³⁴^ORCID,Obianom Obinna N.⁵⁶⁷⁸^ORCID,Ai Yong⁵⁶⁷⁸^ORCID

Affiliation:

1. College of Pharmacy

2. Hubei University of Chinese Medicine

3. Hubei 430065

4. PR China

5. Department of Pharmaceutical Sciences

6. University of Maryland School of Pharmacy

7. Baltimore

8. USA

Abstract

Novel hybrids derived from aspirin and chalcones were designed and synthesized. 7h had potent and selective anti-proliferative activity against CRC cells in vitro. 7h induced cell cycle arrest and apoptosis in CRC cells. 7h significantly inhibited the growth of implanted CRC cancer in mice.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00284C

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