Concise syntheses of (+)-maximumins B and C and (+)-ottensinin-Reference-Cited by-同舟云学术

Concise syntheses of (+)-maximumins B and C and (+)-ottensinin

Published:2024 Issue:18 Volume:11 Page:5160-5166
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Qing-Xin¹²,Wang Lin-Lin³⁴,Zheng Yue-Ming²³,Gao Zhao-Bing²³⁴^ORCID,Zhao Jin-Xin¹²^ORCID,Yue Jian-Min¹²⁴^ORCID

Affiliation:

1. Ethnomedicine and Biofunctional Molecule Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. University of Chinese Academy of Science, No. 19A Yuquan Road, Beijing 100049, China

3. Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China

4. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China

Abstract

Three rearranged labdane diterpenoids, featuring a common 3-substituted γ-pyrone, were effectively synthesized with the longest linear sequences of 4–12 steps. The in-depth pharmacological screening unveiled (+)-ottensinin as a potent KCNQ2 agonist.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00878B

Reference41 articles.

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4. Hapmnioides A–C, Rearranged Labdane-Type Diterpenoids from the Chinese Liverwort Haplomitrium mnioides

5. Hypophyllins A–D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya “Rosea”