Platinum(ii)–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function-Reference-Cited by-同舟云学术

Platinum(ii)–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

Published:2017 Issue:11 Volume:9 Page:1548-1561
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Macedo Taís S.¹²³⁴,Villarreal Wilmer⁵⁶⁷⁴^ORCID,Couto Camila C.¹²³⁴,Moreira Diogo R. M.¹²³⁴^ORCID,Navarro Maribel⁸⁹⁶¹⁰⁴,Machado Marta¹¹¹²¹³¹⁴¹⁵,Prudêncio Miguel¹¹¹²¹³¹⁴¹⁵,Batista Alzir A.⁵⁶⁷⁴,Soares Milena B. P.¹²³⁴¹⁶^ORCID

Affiliation:

1. FIOCRUZ

2. Instituto Gonçalo Moniz

3. Salvador

4. Brazil

5. UFSCAR

6. Departamento de Química

7. São Carlos

8. UFJF

9. ICE

10. Juiz de Fora

11. Instituto de Medicina Molecular

12. Faculdade de Medicina

13. Universidade de Lisboa

14. 1649-028 Lisboa

15. Portugal

16. Centro de Biotecnologia e Terapia Celular

Abstract

The complexes are multistage antimalarial agents, where activity is dependent on the presence of chloroquine on their composition and activity is achieved by impairment of hemozoin formation and disruption of mitochondria.

Funder

Fundação de Amparo à Pesquisa do Estado da Bahia

Fundação para a Ciência e a Tecnologia

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MT/C7MT00196G

Reference34 articles.

1. Malaria: Global progress 2000 – 2015 and future challenges