A high-fat diet induced depression-like phenotype <i>via</i> hypocretin-HCRTR1 mediated inflammation activation-Reference-Cited by-同舟云学术

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A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation

Published:2024 Issue:17 Volume:15 Page:8661-8673
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Dong Jingyi¹,Zhang Jinghui¹,Cheng Shangping¹,Qin Bin¹,Jin Kangyu²,Chen Bing²,Zhang Yuyan¹,Lu Jing¹²³^ORCID

Affiliation:

1. School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China

2. Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, China

3. Zhejiang Key Laboratory of Precision psychiatry, Hangzhou 310003, China

Abstract

HFD tips gut microbiota balance via the gut-brain axis perturbs cerebral equilibrium, increases hypocretin levels, and triggers microglial activation. This leads to inflammation and may cause mental disorders like depression and anxiety.

Funder

Medical Science and Technology Project of Zhejiang Province

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO00210E

Reference51 articles.

1. Western diet is associated with a smaller hippocampus: a longitudinal investigation

2. Signaling pathways underlying the rapid antidepressant actions of ketamine

3. Insulin in the Brain: Sources, Localization and Functions

4. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

5. Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

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