Quality by Design (QbD) approach for the development of a rapid UHPLC method for simultaneous determination of aglycone and glycoside forms of isoflavones in dietary supplements-Reference-Cited by-同舟云学术

Quality by Design (QbD) approach for the development of a rapid UHPLC method for simultaneous determination of aglycone and glycoside forms of isoflavones in dietary supplements

Published:2020 Issue:16 Volume:12 Page:2082-2092
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Lasić Kornelija¹²³⁴⁵^ORCID,Mornar Ana⁶⁷⁸⁴⁵^ORCID,Nigović Biljana⁶⁷⁸⁴⁵

Affiliation:

1. R&D

2. PLIVA Croatia Ltd

3. TEVA Group Member

4. 10000 Zagreb

5. Croatia

6. Department of Pharmaceutical Analysis

7. University of Zagreb

8. Faculty of Pharmacy and Biochemistry

Abstract

Systematic development of a UHPLC method by QbD approach as performed for simultaneous determination of aglycone (genistein, daidzein, biochanin A and formononetin) and glycoside (genistin, daidzin, sissotrin, ononin) forms of isoflavones.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/C9AY02778E

Reference31 articles.

1. V. R. Preedy , Isoflavones : Chemistry, Analysis, Function and Effects , Royal Society Of Chemistry , Cambridge, United Kingdom , 2012

2. Toxicological Assessment of Furocoumarins in Foodstuffs

3. Phytoestrogens and their effects

4. Lipophilicity and bio‐mimetic properties determination of phytoestrogens using ultra‐high‐performance liquid chromatography

5. Aspects of the “Design Space” in high pressure liquid chromatography method development

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