MetDFBA: incorporating time-resolved metabolomics measurements into dynamic flux balance analysis-Reference-Cited by-同舟云学术

MetDFBA: incorporating time-resolved metabolomics measurements into dynamic flux balance analysis

Published:2015 Issue:1 Volume:11 Page:137-145
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Willemsen A. Marcel¹²³⁴⁵^ORCID,Hendrickx Diana M.⁶⁷⁸⁹¹⁰,Hoefsloot Huub C. J.⁶⁷⁸⁹¹⁰,Hendriks Margriet M. W. B.¹¹¹²⁹,Wahl S. Aljoscha¹³¹⁴¹⁵⁹,Teusink Bas¹⁶¹⁷¹⁸⁹,Smilde Age K.⁶⁷⁸⁹¹⁰,van Kampen Antoine H. C.¹²³⁴⁵

Affiliation:

1. Bioinformatics Laboratory

2. Department of Clinical Epidemiology

3. Biostatistics and Bioinformatics

4. Academical Medical Centre

5. Amsterdam

6. Biosystems Data Analysis

7. Swammerdam Institute for Life Sciences

8. University of Amsterdam

9. The Netherlands

10. Netherlands Metabolomics Centre

11. DSM Biotechnology Center

12. Delft

13. Kluyver Centre for Genomics of Industrial Fermentation

14. Biotechnology Department

15. Delft University of Technology

16. Systems Bioinformatics

17. Centre for Integrative Bioinformatics

18. Free University of Amsterdam

Abstract

This paper presents MetDFBA, a new approach incorporating experimental metabolomics time-series into constraint-based modeling. The method can be used for hypothesis testing and predicting dynamic flux profiles.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C4MB00510D

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