Amidosquaramides – a new anion binding motif with pH sensitive anion transport properties-Reference-Cited by-同舟云学术

Amidosquaramides – a new anion binding motif with pH sensitive anion transport properties

Published:2022 Issue:35 Volume:20 Page:7056-7066
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Marchetti Luke A.¹,Krämer Tobias¹^ORCID,Elmes Robert B. P.¹²^ORCID

Affiliation:

1. Department of Chemistry, National University of Ireland Maynooth, Maynooth, Ireland

2. Synthesis and Solid State Pharmaceutical Centre (SSPC), Ireland

Abstract

We report a family of amidosquaramides with pKa values close to physiological pH. Intramolecular H-bonding affects anion binding leading to moderate Cl− transmembrane transport at physiological pH, but under acidic conditions anion transport is effectively ‘switched on’.

Funder

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01176J

Reference36 articles.

1. The Versatility of Squaramides: From Supramolecular Chemistry to Chemical Biology

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3. Squaramide as a binding unit in molecular recognition