Polymer–prodrug conjugates as candidates for degradable, long-acting implants, releasing the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine-Reference-Cited by-同舟云学术

Polymer–prodrug conjugates as candidates for degradable, long-acting implants, releasing the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine

Published:2023 Issue:48 Volume:11 Page:11532-11543
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Liu Chung¹²³,Hern Faye Y.¹²³,Shakil Anika¹²³,Temburnikar Kartik⁴,Chambon Pierre¹²³,Liptrott Neill³⁵^ORCID,McDonald Tom O.¹²³^ORCID,Neary Megan²³⁵,Flexner Charles⁴,Owen Andrew²³⁵,Meyers Caren Freel⁴,Rannard Steve P.¹²³^ORCID

Affiliation:

1. Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK

2. Materials Innovation Factory, University of Liverpool, Crown Street, L69 7ZD, UK

3. Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, L7 3NY, UK

4. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD, 21205, USA

5. Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L7 3NY, UK

Abstract

Emtricitabine, has been modified to form a series of diol monomers for pendant polymer–prodrug conjugate synthesis. Screening has identified structures for implant formation able to release parent drug via enzymatic cleavage mechanisms.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D3TB02268D

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