New pentacyclic triterpenoids isolated from Leptopus chinensis and their hepatoprotective activities on tert-butyl hydroperoxide-induced oxidative injury
Author:
Affiliation:
1. School of Traditional Chinese Materia Medica
2. Shenyang Pharmaceutical University
3. Shenyang 110016
4. People's Republic of China
5. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education
6. School of Pharmacy
Abstract
Eight new triterpenoids and eight known analogues were first obtained from Leptopus chinensis. Among them, compounds 2, 5 and 16 showed the significant hepatoprotective effects against oxidative injury induced by t-BHP in HepG2 cells.
Funder
Natural Science Foundation of Liaoning Province
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA00962A
Reference27 articles.
1. The global burden of liver disease: The major impact of China
2. Anticancer potential of medicinal plants and their phytochemicals: a review
3. Natural products as leads to anticancer drugs
4. Hepatoprotective natural triterpenoids
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1. New triterpenoids from the aerial parts of the Uygur medicine Salvia deserta;Journal of Asian Natural Products Research;2023-12-09
2. Pentacyclic triterpenoids from the Leptopus yunnanensis P. T. Li and their chemotaxonomic significance;Biochemical Systematics and Ecology;2022-08
3. Triterpenoids as Reactive Oxygen Species Modulators of Cell Fate;Chemical Research in Toxicology;2022-03-21
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