“CLipP”ing on lipids to generate antibacterial lipopeptides-Reference-Cited by-同舟云学术

“CLipP”ing on lipids to generate antibacterial lipopeptides

Published:2020 Issue:22 Volume:11 Page:5759-5765
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yim Victor¹²³⁴⁵^ORCID,Kavianinia Iman¹²³⁴⁶^ORCID,Knottenbelt Melanie K.⁷⁸⁹¹⁰⁴,Ferguson Scott A.⁷⁸⁹¹⁰⁴^ORCID,Cook Gregory M.⁷⁸⁹¹⁰⁴,Swift Simon¹¹⁸²¹²⁴^ORCID,Chakraborty Aparajita¹²³⁴⁶,Allison Jane R.¹²³⁴⁶^ORCID,Cameron Alan J.¹²³⁴⁶,Harris Paul W. R.¹²³⁴⁶^ORCID,Brimble Margaret A.¹²³⁴⁶^ORCID

Affiliation:

1. School of Biological Sciences

2. University of Auckland

3. Auckland 1010

4. New Zealand

5. School of Chemical Sciences

6. Maurice Wilkins Centre for Molecular Biodiscovery

7. Department of Microbiology and Immunology

8. School of Medical Sciences

9. University of Otago

10. Dunedin 9054

11. Department of Molecular Medicine and Pathology

12. Auckland 1023

Abstract

We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology.

Funder

Health Research Council of New Zealand

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC01814G

Reference26 articles.

1. Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

2. Lipopeptides: from self-assembly to bioactivity

3. Bacterial resistance to cationic antimicrobial peptides