“CLipP”ing on lipids to generate antibacterial lipopeptides

Author:

Yim Victor12345ORCID,Kavianinia Iman12346ORCID,Knottenbelt Melanie K.789104,Ferguson Scott A.789104ORCID,Cook Gregory M.789104,Swift Simon1182124ORCID,Chakraborty Aparajita12346,Allison Jane R.12346ORCID,Cameron Alan J.12346,Harris Paul W. R.12346ORCID,Brimble Margaret A.12346ORCID

Affiliation:

1. School of Biological Sciences

2. University of Auckland

3. Auckland 1010

4. New Zealand

5. School of Chemical Sciences

6. Maurice Wilkins Centre for Molecular Biodiscovery

7. Department of Microbiology and Immunology

8. School of Medical Sciences

9. University of Otago

10. Dunedin 9054

11. Department of Molecular Medicine and Pathology

12. Auckland 1023

Abstract

We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology.

Funder

Health Research Council of New Zealand

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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