Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal-Reference-Cited by-同舟云学术

Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal

Published:2022 Issue:9 Volume:12 Page:5648-5655
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kumar Prateek¹,Bhardwaj Taniya¹,Giri Rajanish¹^ORCID

Affiliation:

1. Indian Institute of Technology Mandi, School of Basic Sciences, VPO Kamand, Himachal Pradesh 175005, India

Abstract

SARS-CoV-2 NSP1 is believed to be a potential drug target. Its C-terminal region which associates with ribosomal subunit has shown good binding with an anticancer drug, Mitoxantrone.

Funder

Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA07434B

Reference34 articles.

1. Ultrastructure and Origin of Membrane Vesicles Associated with the Severe Acute Respiratory Syndrome Coronavirus Replication Complex

2. SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs

3. Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

4. SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

5. SARS-CoV-2 NSP1 C-terminal (residues 131–180) is an intrinsically disordered region in isolation

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Uncoupling the functional roles of Coronavirus Nsp1;2024-08-05

2. The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections;Biochemical Society Transactions;2024-02-22

3. Antiviral responses versus virus-induced cellular shutoff: a game of thrones between influenza A virus NS1 and SARS-CoV-2 Nsp1;Frontiers in Cellular and Infection Microbiology;2024-02-05

4. An Evolutionarily Conserved Strategy for Ribosome Binding and Host Translation Inhibition by β-coronavirus Non-structural Protein 1;Journal of Molecular Biology;2023-10

5. In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g;Genes & Development;2023-09-01