Discovery of four modified classes of triterpenoids delineated a metabolic cascade: compound characterization and biomimetic synthesis-Reference-Cited by-同舟云学术

Discovery of four modified classes of triterpenoids delineated a metabolic cascade: compound characterization and biomimetic synthesis

Published:2021 Issue:28 Volume:12 Page:9831-9838
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhou Bin¹²³⁴⁵^ORCID,Gao Xin-Hua¹²³⁴⁵^ORCID,Zhang Min-Min⁶¹²³⁴,Zheng Cheng-Yu¹²³⁴⁵,Liu Hong-Chun⁶¹²³⁴,Yue Jian-Min¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Drug Research

2. Shanghai Institute of Materia Medica

3. Chinese Academy of Sciences

4. Shanghai 201203

5. People's Republic of China

6. Division of Anti-tumor Pharmacology

Abstract

Characterization of four classes of highly modified triterpenoids from Dichapetalum gelonioides sheds light on an unprecedented biosynthetic cascade, which was validated by the subsequent biomimetic syntheses. Moreover, some isolates exhibited nanomolar cytotoxic activities.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02710G

Reference51 articles.

1. Nature-inspired cascade catalysis: reaction control through substrate concentration—double vs. quadruple domino reactions