Adapting decarbonylation chemistry for the development of prodrugs capable of in vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules-Reference-Cited by-同舟云学术

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Adapting decarbonylation chemistry for the development of prodrugs capable of in vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules

Published:2021 Issue:31 Volume:12 Page:10649-10654
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

De La Cruz Ladie Kimberly¹²³⁴,Yang Xiaoxiao¹²³⁴,Menshikh Anna⁵⁶⁷⁸⁴,Brewer Maya⁵⁶⁷⁸⁴,Lu Wen¹²³⁴,Wang Minjia⁹¹⁰⁴,Wang Siming¹²³⁴,Ji Xingyue¹²³⁴,Cachuela Alyssa¹²³⁴,Yang Haichun¹¹⁷⁸⁴,Gallo David¹²¹³¹⁴¹⁵⁴,Tan Chalet⁹¹⁰⁴,Otterbein Leo¹²¹³¹⁴¹⁵⁴,de Caestecker Mark⁵⁶⁷⁸⁴,Wang Binghe¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Georgia State University

3. Atlanta

4. USA

5. Department of Medicine

6. Division of Nephrology

7. Vanderbilt University Medical Center

8. Nashville

9. Department of Pharmaceutics and Drug Delivery

10. University of Mississippi

11. Department of Pathology, Microbiology, and Immunology

12. Department of Surgery

13. Beth Israel Deaconess Medical Center

14. Harvard Medical School

15. Boston

Abstract

1,2-Dicarbonyl compounds with FDA-approved sweeteners as leaving groups deliver CO for protection against acute kidney injury in mice.

Funder

National Institutes of Health

Georgia Research Alliance

Georgia State University

Department of Defense

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02711E

Reference62 articles.

1. The therapeutic potential of carbon monoxide

2. Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

3. Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles

4. Role of Carbon Monoxide in Kidney Function: Is a little Carbon Monoxide Good for the Kidney?

5. Carbon monoxide: An emerging therapy for acute kidney injury

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