An efficient Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in aqueous medium with a zwitterionic ligand, betaine
Author:
Affiliation:
1. Department of Chemistry
2. Korea Advanced Institute of Science and Technology (KAIST)
3. Daejeon
4. Korea
5. The 4th R&D Institute-2
6. Agency for Defense Development
Abstract
Betaine, a simple zwitterionic additive, dramatically accelerated the CuAAC reaction in excellent yields under 2.5–200 ppm levels of Cu(I) in water.
Publisher
Royal Society of Chemistry (RSC)
Subject
Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2017/CY/C7CY00518K
Reference39 articles.
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4. Advances of azide-alkyne cycloaddition-click chemistry over the recent decade
5. Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
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