Measuring tryptophan dynamics using fast scan cyclic voltammetry at carbon fiber microelectrodes with improved sensitivity and selectivity

Author:

Schapira Isabella1,O'Neill Margaret R.1,Russo-Savage Lillian2,Narla Terdha3,Laprade Kathryn A.4,Stafford James M.24,Ou Yangguang12ORCID

Affiliation:

1. Department of Chemistry, University of Vermont, USA

2. Neuroscience Graduate Program, University of Vermont, USA

3. Department of Pharmacology, University of Vermont, USA

4. Department of Neurological Sciences, University of Vermont, USA

Abstract

Here we report an optimized sawhorse waveform in fast scan cyclic voltammetry for the sensitive and selective detection of tryptophan (Trp) at carbon fiber microelectrodes and demonstrate the utility of this method in measuring Trp dynamics in different cell lines.

Funder

University of Vermont

Defense Advanced Research Projects Agency

711th Human Performance Wing

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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