Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1selectivity-Reference-Cited by-同舟云学术

Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1selectivity

Published:2015 Issue:7 Volume:6 Page:1340-1344
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zlotos Darius P.¹²³⁴,Riad Noura M.¹²³⁴,Osman Mai B.¹²³⁴,Dodda Bala R.⁵⁶⁷⁸⁹,Witt-Enderby Paula A.⁵⁶⁷⁸⁹

Affiliation:

1. Department of Pharmaceutical Chemistry

2. The German University in Cairo

3. New Cairo City

4. Egypt

5. Division of Pharmaceutical Sciences

6. School of Pharmacy

7. Duquesne University

8. 421 Mellon Hall

9. Pittsburgh

Abstract

The difluoroacetamide analogue of the standard MT₁-selective ligand, the dimeric (CH₂)₃-linked agomelatine, shows higher affinity and selectivity toward MT₁receptors than the parent compound.

Funder

German Academic Exchange Service

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00190K

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