Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1selectivity-Reference-Cited by-同舟云学术

Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1selectivity

Published:2015 Issue:7 Volume:6 Page:1340-1344
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zlotos Darius P.¹²³⁴,Riad Noura M.¹²³⁴,Osman Mai B.¹²³⁴,Dodda Bala R.⁵⁶⁷⁸⁹,Witt-Enderby Paula A.⁵⁶⁷⁸⁹

Affiliation:

1. Department of Pharmaceutical Chemistry

2. The German University in Cairo

3. New Cairo City

4. Egypt

5. Division of Pharmaceutical Sciences

6. School of Pharmacy

7. Duquesne University

8. 421 Mellon Hall

9. Pittsburgh

Abstract

The difluoroacetamide analogue of the standard MT₁-selective ligand, the dimeric (CH₂)₃-linked agomelatine, shows higher affinity and selectivity toward MT₁receptors than the parent compound.

Funder

German Academic Exchange Service

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00190K

Reference25 articles.

1. Melatonin receptors step into the light: cloning and classification of subtypes

2. M. L. Dubocovich , D. P.Cardinali, P.Delagrange, D. N.Krause, A. D.Strosberg, D.Sugden and F. D.Yocca, in The IUPHAR compendium of receptor characterization and classification, ed. D. Girdlestone, IUPHAR Media, London, 2000, pp. 271–277

3. MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential

4. Targeted Disruption of the Mouse Mel 1b Melatonin Receptor

5. Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Melatonin–vorinostat hybrid ligands show higher histone deacetylase and cancer cell growth inhibition than vorinostat;Archiv der Pharmazie;2023-06-20

2. Melatonin receptor ligands: A pharmaco‐chemical perspective;Journal of Pineal Research;2020-07-05

3. Virtual discovery of melatonin receptor ligands to modulate circadian rhythms;Nature;2020-02-10

4. Indole-based melatonin analogues: Synthetic approaches and biological activity;European Journal of Medicinal Chemistry;2020-01

5. O-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors;Bioorganic Chemistry;2019-04