Tensile force field plays a crucial role in local invasion of tumor cells through a mechano-chemical coupling mechanism

Author:

Meng Jianfeng123,Xu Xiangyu24,Jiang Chaohui12,Xia Peng5,Xu Pengfei6,Tian Liangfei7,Xu Yingke7ORCID,Li Dechang1ORCID,Tan Youhua3ORCID,Ji Baohua18ORCID

Affiliation:

1. Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China

2. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China

3. Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China

4. Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China

5. Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Science Institute, Zhejiang University, Hangzhou 310058, China

6. School of Medicine, Zhejiang University, Hangzhou 310058, China

7. MOE Key Laboratory of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China

8. Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310027, China

Abstract

Cell polarization and migration during tumor cell invasion are closely associated with the tensional force field in the fiber network, which revealed a mechano-chemical coupling mechanism at the cellular level of the tumor invasion process.

Funder

National Natural Science Foundation of China

Science, Technology and Innovation Commission of Shenzhen Municipality

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

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