Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells-Reference-Cited by-同舟云学术

Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells

Published:2022 Issue:40 Volume:12 Page:26372-26381
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Brickute Diana¹,Chen Cen¹,Braga Marta¹,Barnes Chris¹,Wang Ning¹,Allott Louis²³^ORCID,Aboagye Eric O.¹

Affiliation:

1. Comprehensive Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

2. Positron Emission Tomography Research Centre, Faculty of Health Sciences, University of Hull, Cottingham Road, Kingston upon Hull, HU6 7RX, UK

3. Department of Biomedical Sciences, Faculty of Health Sciences, University of Hull, Cottingham Road, Kingston upon Hull, HU6 7RX, UK

Abstract

Lipofuscin deposits in senescence cells are visualised using the pathology stain Sudan Black B (SBB), an emerging biomarker of senescence. This work develops and evaluates a fluorine-18 derivative for positron emission tomography (PET) imaging.

Funder

Medical Research Council

Cancer Research UK

NIHR Imperial Biomedical Research Centre

Imperial College London

EPSRC Centre for Doctoral Training in Medical Imaging

Imperial Experimental Cancer Medicine Centre

King's College London

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04535D

Reference21 articles.

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4. Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer

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