An iron-containing ferritin-based nanosensitizer for synergistic ferroptosis/sono-photodynamic cancer therapy

Author:

Zheng Yilin1,Zheng Jianping2ORCID,Du Manyi1,Yang Ya1,Li Xudong1,Chen Haijun3ORCID,Gao Yu1ORCID

Affiliation:

1. Cancer Metastasis Alert and Prevention Center, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China

2. Department of Oncology, Shengli Clinical Medical College of Fujian Medical University&Fujian Provincial Hospital, Fuzhou, Fujian 350001, China

3. Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China

Abstract

A ferritin-based nanosensitizer FCD by co-encapsulating chlorin e6 (Ce6) and dihydroartemisinin (DHA) in horse spleen ferritin was constructed, and was employed for synergistic ferroptosis and sono-photodynamic therapy (SPDT).

Funder

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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