Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal-Reference-Cited by-同舟云学术

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Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal

Published:2016 Issue:56 Volume:6 Page:51367-51373
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Honcharenko M.¹²³⁴,Bestas B.⁵⁶²⁷⁸,Jezowska M.¹²³⁴,Wojtczak B. A.⁹¹⁰¹¹¹²,Moreno P. M. D.⁵⁶²⁷⁸,Romanowska J.¹²³⁴¹³,Bächle S. M.¹⁴¹⁵²⁷¹⁶,Darzynkiewicz E.⁹¹⁰¹¹¹²¹⁷,Jemielity J.⁹¹⁰¹¹¹²^ORCID,Smith C. I. E.⁵⁶²⁷⁸,Strömberg R.¹²³⁴

Affiliation:

1. Department of Biosciences and Nutrition

2. Karolinska Institutet

3. SE-14183 Huddinge

4. Sweden

5. Clinical Research Center

6. Department of Laboratory Medicine

7. Karolinska University Hospital Huddinge

8. SE-141 86 Huddinge

9. Centre of New Technologies

10. University of Warsaw

11. 02-097 Warsaw

12. Poland

13. Institute of Bioorganic Chemistry

14. Center for Infectious Medicine

15. Department of Medicine

16. 14186 Stockholm

17. Division of Biophysics

Abstract

Minimal requirement for Snurportin based nuclear uptake is the inclusion of a trinucleotide sequence between the m₃G-CAP and the artificial linker.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA09568B

Reference38 articles.

1. Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer

2. Functional Architecture of the Nuclear Pore Complex

3. The nuclear pore complex – structure and function at a glance

4. Permeability of Single Nuclear Pores

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