Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization-Reference-Cited by-同舟云学术

Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization

Published:2015 Issue:21 Volume:51 Page:4488-4491
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Tolnai Gergely L.¹²³⁴⁵,Székely Anna¹²³⁴⁵,Makó Zita¹²³⁴⁵,Gáti Tamás⁶⁷⁸,Daru János⁹¹⁰¹¹⁸,Bihari Tamás⁹¹⁰¹¹⁸,Stirling András⁹¹⁰¹¹⁸,Novák Zoltán¹²³⁴⁵

Affiliation:

1. MTA-ELTE “Lendület” Catalysis and Organic Synthesis Research Group

2. Institute of Chemistry

3. Eötvös University

4. Faculty of Science

5. Budapest

6. Servier Research Institute of Medicinal Chemistry

7. H-1031 Budapest

8. Hungary

9. Research Centre for Natural Sciences of the Hungarian Academy of Sciences

10. Department of Theoretical Chemistry

11. 1117 Budapest

Abstract

Metal free direct trifluoroethylation of unprotected indoles at position 3 via C–H functionalization is presented: straightforward synthesis and DFT studies.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC00519A

Reference74 articles.

1. Late-Stage Fluorination: Fancy Novelty or Useful Tool?

2. Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

3. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

4. Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

5. Organofluorine chemistry: applications, sources and sustainability

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