The role of iron in doxorubicin-induced cardiotoxicity: recent advances and implication for drug delivery-Reference-Cited by-同舟云学术

The role of iron in doxorubicin-induced cardiotoxicity: recent advances and implication for drug delivery

Published:2021 Issue: Volume: Page:
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Qin Yan¹²³⁴⁵^ORCID,Guo Tao⁶⁷⁸,Wang Zheng¹²³⁴⁵,Zhao Yanjun¹²³⁴⁵^ORCID

Affiliation:

1. School of Pharmaceutical Science & Technology

2. Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency

3. and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

4. Tianjin University

5. Tianjin 300072

6. Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital

7. Tianjin 300120

8. China

Abstract

Doxorubicin administration induces the impairment of iron homeostasis and ferroptosis of cardiomyocytes. The delivery of iron chelators and radical trapping agents could inhibit ferroptotic cell death to relieve doxorubicin-induced cardiotoxicity.

Funder

Tianjin Research Program of Application Foundation and Advanced Technology of China

Shenzhen Science and Technology Innovation Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D1TB00551K

Reference121 articles.

1. Clinical Evaluation of Adriamycin, a New Antitumour Antibiotic

2. Clinical trials with adriamycin

3. Doxorubicin: The Good, the Bad and the Ugly Effect

4. Chemotherapy and Cardiotoxicity in Older Breast Cancer Patients: A Population-Based Study

5. Identification of the molecular basis of doxorubicin-induced cardiotoxicity

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