Pharmacophore generation and atom based 3D-QSAR of quinoline derivatives as selective phosphodiesterase 4B inhibitors-Reference-Cited by-同舟云学术

Pharmacophore generation and atom based 3D-QSAR of quinoline derivatives as selective phosphodiesterase 4B inhibitors

Published:2016 Issue:79 Volume:6 Page:75805-75819
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sharma Vidushi¹²³⁴⁵,Kumar Hirdesh⁶⁷⁸⁹,Wakode Sharad¹²³⁴⁵

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR)

3. University of Delhi

4. New Delhi – 110017

5. India

6. Parasitology – Center for Infectious Diseases

7. University of Heidelberg Medical School

8. 69120 Heidelberg

9. Germany

Abstract

Reported PDE4B inhibitors were used to design QSAR based pharmacophore model. Using developed pharmacophore model, virtual screening was performed followed by cross-docking to identify novel PDE4B specific inhibitors.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA11210B

Reference46 articles.

1. Recent Advances in PDE4 Inhibitors as Immunoregulators and Anti- Inflammatory Drugs

2. Highly Selective Phosphodiesterase 4 Inhibitors for the Treatment of Allergic Skin Diseases and Psoriasis

3. Evidence for a Role of Phosphodiesterase 4 in Lipopolysaccharide-Stimulated Prostaglandin E2 Production and Matrix Metalloproteinase-9 Activity in Human Amniochorionic Membranes

4. Effects of Vesnarinone on Morbidity and Mortality in Patients with Heart Failure

5. Sildenafil, a novel effective oral therapy for male erectile dysfunction

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