Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1-Reference-Cited by-同舟云学术

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Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1

Published:2018 Issue:26 Volume:8 Page:14335-14346
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Barakat Assem¹²³⁴⁵^ORCID,Islam Mohammad Shahidul¹²³⁴⁵^ORCID,Ghawas Hussien Mansur¹²³⁴⁵,Al-Majid Abdullah Mohammed¹²³⁴⁵,El-Senduny Fardous F.¹⁶⁷⁸⁹^ORCID,Badria Farid A.¹⁰¹¹⁷¹²⁹,Elshaier Yaseen A. M. M.¹³¹¹¹⁴¹⁵⁹,Ghabbour Hazem A.¹⁶¹⁷³⁴⁵

Affiliation:

1. Department of Chemistry

2. College of Science

3. King Saud University

4. Riyadh 11451

5. Saudi Arabia

6. Faculty of Science

7. Mansoura University

8. Mansoura

9. Egypt

10. Department of Pharmacognosy

11. Faculty of Pharmacy

12. Mansoura 35516

13. Pharmaceutical Organic Chemistry Department

14. Al-Azhar University

15. Assuit 71524

16. Department of Pharmaceutical Chemistry

17. College of Pharmacy

Abstract

Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA02358A

Reference46 articles.

1. Overview of PDEs and Their Regulation

2. Targeting cancer with phosphodiesterase inhibitors

3. A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.

4. Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy

5. Potency, selectivity, and consequences of nonselectivity of PDE inhibition

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