Fine chemical syntheses under flow using SiliaCat catalysts

Author:

Ciriminna Rosaria1234,Pandarus Valerica567,Béland François567,Pagliaro Mario1234

Affiliation:

1. Istituto per lo Studio dei Materiali Nanostrutturati

2. CNR

3. 90146 Palermo

4. Italy

5. SiliCycle

6. Québec

7. G1P 4S6 Canada

Abstract

After reviewing selected recent applications from diverse laboratories, we show how mesoporous organosilica-entrapped catalysts of the SiliaCat series have been successfully used for clean manufacturing of APIs in a number of different reactions carried out under laminar flow in microreactors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Reference46 articles.

1. Novel Process Windows, ed. V. Hessel, D. Kralisch and N. Kockmann, Weinheim, Wiley-VCH, 2015

2. SiliaCat: A Versatile Catalyst Series for Synthetic Organic Chemistry

3. W. R. Reynolds and C. G.Frost, Coupling Reactions in Continuous-Flow Systems In Palladium-Catalyzed Coupling Reactions: Practical Aspects and Future Developments, ed. A. Molnár, Weinheim, Wiley-VCH, 2013, pp. 409–443

4. Mixing and Dispersion in Small-Scale Flow Systems

5. Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

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