Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties-Reference-Cited by-同舟云学术

Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties

Published:2017 Issue:9 Volume:15 Page:2104-2118
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Verhasselt Sigrid¹²³⁴⁵^ORCID,Roman Bart I.¹²³⁴⁵^ORCID,De Wever Olivier⁶⁷³⁴⁵,Van Hecke Kristof⁸³⁴⁵^ORCID,Van Deun Rik⁸³⁴⁵^ORCID,Bracke Marc E.⁶⁷³⁴⁵,Stevens Christian V.¹²³⁴⁵^ORCID

Affiliation:

1. SynBioC Research Group

2. Department of Sustainable Organic Chemistry and Technology

3. Ghent University

4. 9000 Ghent

5. Belgium

6. Laboratory of Experimental Cancer Research

7. Department of Radiation Oncology and Experimental Cancer Research

8. Department of Inorganic and Physical Chemistry

Abstract

Chemical optimization of (S)-blebbistatin resulted in the discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin, myosin II inhibitors with superior research tool properties.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00006E

Reference40 articles.

1. Structural and Functional Insights into the Myosin Motor Mechanism

2. L. M. Coluccio , Myosins: A superfamily of molecular motors, Springer, Netherlands, 2008

3. Non-muscle myosin II takes centre stage in cell adhesion and migration

4. Small-molecule inhibitors of myosin proteins

5. Specificity of blebbistatin, an inhibitor of myosin II

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